Today, more than 30,000 fragments of medieval manuscripts can be found in hundreds of North American collections, and yet such fragments are often dismissed by scholars as unworthy of study and by librarians as too difficult to catalogue. On the contrary. Fragments represent a largely-untapped source of research topics and teaching opportunities, but they must be found, imaged, and catalogued before they can be used for investigation and pedagogy. Fragments that are imaged and catalogued in open-access applications that enable discoverability and facilitate interoperability have enormous potential for research and discovery. This webinar will review the 500-year history of fragmentation, discuss strategies for fragment research and description, and introduce the methods and methodologies of digital fragmentology.